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The Daroff-Dell'Osso Ocular Motility Laboratory
(OMLAB)


An Endowed Laborartory of
CASE School of Medicine and Case Western Reserve University
Located in the
Louis Stokes Cleveland Department of Veterans Affairs Medical Center
Cleveland, Ohio, USA

Measurement of Human Eye Movements to Study Neurological, Visual, and Vestibular Disorders; Ocular Motor System Function and Dysfunction

Areas of Specialization: Systems and Computational Neurobiology, Ocular Motor Oscillations (Nystagmus and Saccadic), Ocular Motor System Models, Nystagmus Therapies, Vision and Balance, Vestibular Function, Version-Vergence Interaction, Eye-Head Interactions, and Retinal Electrophysiology of Visual Disorders

Measurement techniques: Infrared Reflection, Magnetic Search Coil, and High-Speed Digital Video Systems to record eye movements in the horizontal, vertical and torsional planes of humans; Motion Platform and Rotating Chairs to study balance.

Off-Site Research: Because the Daroff-Dell'Osso Ocular Motility Laboratory is designed for the study of human eye movements only, any non-human studies, e.g., on canines and mice, have been carried out by specefic investigators at other facilities in collaboration with investigators based at those facilities.

Links to Recent OMLAB Publications.

EBME319 students click here for laboratory information.

New! [July 1, 2008] Wang ZI and Dell'Osso LF: Behavioral OMS Model v1.4 published in Vision Research.
   Click here to download New and Improved OMS Model v1.4 (.zip).

New! Dell'Osso LF: How Person with INS "Sees" the World and How to Clinically Assess Therapeutic Improvements in Visual Function. OMLAB Report #030509, 1-5, 2009. (Reports & Teaching).
New! Wang ZI and Dell'Osso LF: Factors Influencing Pursuit Ability in Infantile Nystagmus Syndrome. Target Timing and Foveation Capability. Vision Res. (PubMed).
New! Dell'Osso LF and Wang ZI: Extraocular Proprioception and New Treatments for Infantile Nystagmus Syndrome. (PubMed).
[October 2008] Author Response! Wang, Z.I. et al: An Open Letter to the Editor of the NEJM. OMLAB Report #092508, 1-4, 2008. (Reports & Teaching).
[August 6, 2008] Epilog Added: Dell'Osso LF: INOS 2008 - Ethical Science or Something Else? (The "Editorial Page")

INOS Members Need to Knowinos2008 inos 2008
New! Wang, Z.I. and Dell'Osso, L.F.: Behavioral OMS Model v1.4. OMLAB Report #070108, 1-16, 2008. (Reports & Teaching).
NEW BOOK! Advances in Understanding Mechanisms and Treatment of Infantile Forms of Nystagmus. RJ Leigh & MW Devereaux eds. Oxford Univ Press.
Publications from the OMLAB CONFERENCE [May 3-4, 2007] (Conference 2007).
New! Maguire AM, et al: Safety and Efficacy of Gene Transfer for Leber's Congenital Amaurosis. (PubMed).
"From BENCH to BEDSIDE"inos2008 inos 2008
New! Abel LA, et al: Wavelet Analysis in Infantile Nystagmus Syndrome: Limitations and Abilities. (PubMed).
INOS Members Need to Knowinos2008 inos 2008
New! Wang ZI and Dell'Osso LF: Tenotomy Procedure Alleviates the "Slow to See" Phenomenon in Infantile Nystagmus Syndrome: Model Prediction and Patient Data. (PubMed).
New! Taibbi G, et al: Infantile Nystagmus Syndrome: Broadening the High-Foveation-Quality Field with Contact Lenses. Clin. Ophthalmol. 2008. (Free Download)..
New! Serra A, et al: Pseudo-Bruns' Infantile Nystagmus Syndrome: Mechanisms of Jerk Waveforms. (PubMed).
New! Liao K, et al: Abnormal Vestibular Responses to Vertical Head Motion in Cerebellar Ataxia. (PubMed).
New! Bennicelli J, et al: Reversal of Blindness in Animal Models of Leber Congenital Amaurosis Using Optimized AAV2-mediated Gene Transfer. (PubMed).
New! Serra A, et al: Suppression of Saccadic Intrusions in Hereditary Ataxia by Memantine. (PubMed).
New! Liao K, et al: Vestibulo-ocular Responses to Vertical Translation in Normal Human Subjects. (PubMed).
New! Thurtell MJ, et al: Complete Ophthalmoplegia. An Unusual Sign of Bilateral Paramedian Midbrain-Thalamic Infarction. (PubMed).
New! Liao K, et al: Why do Patients with PSP Fall?: Evidence for Abnormal Otolith Responses. (PubMed).
Dell'Osso LF: The Benefits of Extraocular Muscle Surgery in Infantile Nystagmus Syndrome. OMLAB Report #123007, 1-6, 2007. (Reports & Teaching).

INS PATIENT HANDOUTS: 1. INS; 2. INS Treatments; 3. Tenotomy; 4. INS and Acuity; 5. INS Miscellaneous (Reports & Teaching).

CANINE EYE-MOVEMENT VIDEOS: Pre- and Post-Tenotomy (COMLAB).

[September 23, 2008] Updated! Dell'Osso LF: Response to More than a Response: Tenotomy Improves INS Waveforms. OMLAB Report #071107, 1-12, 2007. (Reports & Teaching).inos2008 inos 2008
[May 3-4, 2007] OMLAB CONFERENCE (Conference 2007).
[May 2006] *** Come and browse our new lab space!.

New! [July 22, 2008] Latest updates and bug fixes to OMtools. (Software).
New! [June 6, 2008] Latest update to NAFX contains minor bug fixes and usability enhancements. (Software).

[September 2006] *** Dell'Osso LF: Original Ocular Motor Analysis of the First Human with Achiasma. *** OMLAB Report #090506, 1-21, 2006. (Reports & Teaching).
[November 22, 2005] Dell'Osso LF: Nystagmus Therapies: Types, Sites, and Measures. OMLAB Report #111905, 1-4, 2005. (Reports & Teaching).
[November 21, 2005] Dell'Osso LF: Using the NAFX for Eye-Movement Fixation Data Analysis and Display. OMLAB Report #111005, 1-7, 2005. (Reports & Teaching).
[January 11, 2005] Dell'Osso LF: Recording and Calibrating the Eye Movements of Nystagmus Subjects. OMLAB Report #011105, 1-4, 2005. (Reports & Teaching).

[July 30, 2004] Jacobs JB and Dell'Osso LF: Ocular Motor System model published in the Journal of Vision.
   Click here to read the paper (HTML). <==> Click here to download the paper (PDF).
   Click here to download OMS Model v1.0 (.zip).

Home   |   About OMLAB   |   Personnel   |   Software and OMS Models   |   Reports & Teaching   |   The "Editorial Page"   |   Contact Us 

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